Logos Biosystems X-CLARITY tissue clearing system

Friday, 01 November, 2019 | Supplied by: ATA Scientific Pty Ltd

Conventional tissue imaging techniques require thin tissue sectioning; however, this process can be labour-intensive and is usually prone to errors. Recent advances in tissue clearing technology can now allow visualisation of cellular structures and neural networks inside of unsectioned whole tissues or even the entire body.

The X-CLARITY is an all-in-one system with ready-to-use reagents for simple, rapid and reproducible tissue clearing. The system has been developed to standardise, simplify and accelerate each step of the tissue clearing process, with a design that accelerates the removal of lipids from tissues in an efficient manner. Challenging samples such as bone, spinal cord and plants can be cleared using easy-to-follow workflows. A whole mouse brain takes just 6 h to clear.

With the CLARITY method, preserved tissues are embedded in a hydrogel matrix and lipids are actively extracted through electrophoresis to create a stable and optically transparent tissue-hydrogel hybrid that is chemically accessible for multiple rounds of antibody labelling and imaging. Native cytoarchitecture remains intact and even endogenous fluorescence proteins are preserved for robust fluorescence imaging downstream. Once cleared, tissues can be imaged using confocal, multiphoton or lightsheet microscopes.

Based on the work of the Deisseroth lab in Stanford, the X-CLARITY is suitable for leading research institutes and pharma globally.

For more information: https://www.atascientific.com.au/products/logos-biosystems-x-clarity/.

Online: www.atascientific.com.au
Phone: 02 9541 3500
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