Shimadzu LCMS-8040 system

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By incorporating ion optics and collision cell technology, Shimadzu’s LCMS-8040 provides high multiple reaction monitoring (MRM) sensitivity. A five-fold increase in sensitivity has been achieved by improving ion focusing and minimising ion losses between multipole lenses. These improvements also yield higher sensitivity for scan mode measurements. This higher sensitivity expands the potential range of LC/MS/MS applications.

The product was designed to provide significantly higher sensitivity while maintaining the high speed offered by the LCMS-8030. Ultrafast MRM transition speeds, up to 555 MRMs/s, are achieved by the company’s UFsweeper collision cell technology, high-precision quadrupole machining capabilities and high-voltage power supply technology. In addition, the product is claimed to feature the world’s fastest polarity switching at 15 ms. With this high-speed performance, the product can dramatically improve analytical throughput.

MRM optimisation in the company’s LCMS systems is based on a rapid series of automated flow injection analyses, requiring only minutes to perform. Multiple compounds can be optimised in an unattended sequence, freeing the analyst from tedious work. MRM parameters optimised for the LCMS-8030 can be transferred to the LCMS-8040, making it possible to transfer methods between systems. All consumables, such as desolvation lines (DL) and ESI capillaries, are interchangeable as well.