Thermo Fisher Scientific application note for effective determination of dibasic acids

Tuesday, 29 May, 2012 | Supplied by: Thermo Fisher Scientific

Thermo Fisher Scientific has announced an effective method for the determination of succinic, glutaric and adipic acids in solutions of mixed dibasic acids generated during cyclohexane oxidation.

‘Application Note 285: Determination of Succinic, Glutaric, and Adipic Acids as Quality Control of Cyclohexone Production’ demonstrates use of the company’s liquid chromatography system (Thermo Scientific Dionex UltiMate 3000 RSLC system) with organic acid analytical column (Thermo Scientific Acclaim OA column) and mass spectrometry (MS) detection to achieve a fast baseline separation of these three dibasic acids with good resolution values (Rs ≥2.6), good method reproducibility, good linearity within 0.1 to 5 mg/L and accurate results for industrial samples.

Cyclohexone is the key intermediate for the production of adipic acid, an important compound for the synthesis of nylon 66. Cyclohexane oxidation is the normal method for the production of cyclohexone; and succinic, glutaric and adipic acids, as well as their dehydration products, are the main by-products. The three aliphatic dicarboxylic acids are also important chemical raw materials, and their determination is important for the quality control of cyclohexone production and recycling of the by-products.

This application note and many others can be found at under the Documents tab.

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