Single-run human genome sequencing

Applied Biosystems recently announced that its research and development scientists used human disease samples from the Baylor College of Medicine Human Genome Sequencing Center to sequence an entire human genome in a single run at 17-fold coverage using the SOLiD 3 System.

Data from the high throughput and sequence coverage projects was presented by the HGSC at the Cold Spring Harbor Laboratory Biology of Genomes meeting in New York.

Scientists at the HGSC are currently equipped with 10 SOLiD Systems and are using them for a variety of human disease research programs, spanning cancer and genetic disorders.

The prospect of a single instrument run deciphering an entire human genome was unimaginable a few years ago and now it’s a reality. It is anticipated that the high performance of the SOLiD System, the inherent scalability of the platform and the depth of coverage achieved in single instrument runs will further human disease research projects.