US scientists have modelled an enzyme critical to the process of DNA transcription and replication which could be a prime target for antibacterial and anticancer drugs.
The DynaPro plate reader performs automated, high-throughput, temperature-controlled dynamic light scattering (DLS) measurements with industry-standard well plates without perturbing the samples. This device is designed to achieve rapid screening of unfractionated samples and is suitable for a wide range of applications including protein crystallography, pharmaceutical formulation and antibody aggregation studies. The plate reader uses industry-standard 96, 384 or 1536 well plates and features built-in temperature control as well as compatibility with the industry's liquid handling robots.
The molecular machinery that starts the process by which a biological cell divides into two identical daughter cells apparently worked so well early on that evolution has conserved it across the eons in all forms of life on Earth.
The Bio21 Collaborative Crystallisation Centre (Bio21-C3) is the first of its kind in Australia and will be opened by the Parliamentary Secretary for Innovation and Industry, Matt Viney, MP.
Five years ago, x-ray crystallography made it possible for the first time to study ribosomes in cells, where the synthesis of proteins takes place. But it hasn't been understood just how amino acids are joined together to form proteins. Now researchers at Uppsala University have discovered the only possible mechanism and have used it to explain a number of biochemical experiments.
Monash researcher Dr Jamie Rossjohn has received a Prime Minister's award for his contribution to science.
Using sophisticated computer algorithms running on standard desktop computers, researchers have designed and constructed a novel functional protein that is not found in nature. The achievement should enable researchers to explore larger questions about how proteins evolved and why nature 'chose' certain protein folds over others.
A complete molecular-scale picture of how plants convert sunlight to chemical energy has been obtained at Purdue University in the US, offering potential new insights into animal metabolism as well.