Kinetex LC columns

Phenomenex has introduced Kinetex, ultra-high-performance LC columns based on the company’s core-shell silica technology.

Kinetex is claimed to deliver improvements in speed and separation efficiency over traditional 3- and 5-micron columns; the instrument enables performance comparable to sub-2 micron columns without investing in UHPLC systems.

Researchers can achieve UHPLC results on any LC instrument platform and any chromatographic method can now be completed in considerably less time previously, without sacrificing performance. The increased separation efficiencies of Kinetex also reduce solvent usage and maintain long column life.

Kinetex core-shell technology enables high resolution and sensitivity over an extended linear velocity without generating excessive backpressure. These columns provide roughly twice the efficiency of fully porous 3-micron columns and three times the efficiency of fully porous 5-micron columns and significantly lower limits of detection and quantitation.

Kinetex core-shell columns are available in two particle sizes - 2.6 and 1.7 micron - and three chemistries - C18, PFP and HILIC. Kinetex 2.6-micron columns have good separation efficiencies and the Kinetex 1.7-micron delivers efficiency gains of 15-20% over traditional fully porous sub-2 micron columns.

Methods developed with either 2.6- or 1.7-micron Kinetex columns are scalable and can be transferred to any LC system using the 2.6-micron column, regardless of the instrument’s pressure capability.

The columns enable better resolution of more complex mixtures in less time in both food safety applications, such as the detection of carbamate pesticides, antibiotics, aflatoxins or azo dyes, and environmental analyses, such as detection of explosives, carbamate pesticides and chlorinated herbicides. In drug discovery research and toxicology studies, the speed of analysis can reduce development time on therapeutics such as tricyclic antidepressants, sulfur drugs, beta-blockers, ranitidine and cough and cold medicines. Kinetex also delivers good separations for forensic toxicology applications such as the detection of opiates and other illicit drugs.