Lux Cellulose-4 and Cellulose-3 chiral separation columns

Two polysaccharide-based Lux Columns for HPLC/SFC chiral separations have been added to the Phenomenex range.

The Lux Cellulose-4 is a novel cellulose tris (4-chloro-3-methylephenylcarbamate) phase and the Lux Cellulose-3 uses cellulose tris (4-methylbenzoate) as the selector. Both new columns deliver high efficiency and loading capacity and are pressure-stable up to 300 bar.

Phenomenex has designed a chiral method development wall poster to help guide users through simple screening protocols and users can create their own three-, four- or five-phase screening kits.

The FDA mandates that enantiomers of all chiral drugs in development be screened separately on their pharmacodynamic and pharmacokinetic properties. A chiral compound’s enantiomers may have different pharmacological effects in biological systems. Yet chiral molecules are often difficult to separate and identify using traditional chromatography tools. The identification of chiral molecules is also important in toxicology studies, flavour and fragrance analysis and environmental applications such as pesticide analysis.

Lux columns are offered in 3 and 5 µm particle sizes, packed for analytical-scale use or AXIA-packed for preparative applications. 20 µm bulk media is also available up to the kilogram scale.