MBF Bioscience Vesalius spinning disk confocal microscope

Vesalius, by MBF Bioscience, is a versatile confocal microscope system for fast, large-scale, multichannel 2D and 3D whole-slide imaging of slide-mounted specimens including mouse, rat and non-human primate. It can capture images of thick or thin tissue samples, with customisable imaging options at speeds that are said to be 10x faster than conventional laser scanning confocal microscopes and more than 100x faster than grid-based structured illumination. The product offers high signal-to-noise ratio, minimal photobleaching and elimination of out-of-focus planes, maximising laboratory productivity with its speed and versatility.

Key benefits include scan rates up to 1000 fps and a field of view of up to 25 mm, which translates to fewer tiles for creating montages and performing whole-slide imaging. Multiple imaging modes available include confocal, live cell, widefield, brightfield and darkfield. Slide-mounting options are available including XL slides for large tissue specimens and the unit can accommodate a wide range of objective lenses — from 4x up to 100x.

The product can be fully integrated with existing MBF Bioscience microscopy systems, including Stereo Investigator and Neurolucida. Additionally, it also works well with state-of-the-art components including Zeiss, Olympus, Nikon or Leica optics, ultrasensitive high-resolution cameras, motorised stages and multichannel lasers.

Users can acquire vast amounts of data from standard slides, expansion microscopy or cleared tissue and analyse it with MBF Bioscience’s software solutions that are developed for neuroscience research in collaboration with experts in the advanced microscopy research community.