Thermo Scientific Transcend DSX-1 UHPLC system

Clinical research, toxicology and anti-doping laboratories performing dried spot sampling and analysis can use Thermo Fisher Scientific’s latest automated sample prep and ultrahigh-performance liquid chromatography (UHPLC) system to improve efficiency, robustness, sensitivity and sample traceability. The system was designed to help laboratories to effectively increase throughput to meet demand, while still maintaining the integrity and quality of results that are expected.

The Thermo Scientific Transcend DSX-1 integrated sample prep and UHPLC system eliminates disc punching typically associated with dried matrix (spot) cards, and optimises sample extraction and recovery of multiple matrices (eg, blood, urine, serum and saliva). The system is designed to help laboratories performing routine analysis of drugs and other compounds to achieve savings on time, labour and reagent costs compared to manual workflows.

Proprietary flow-through desorption with heated capillary eliminates the need for manual, time-consuming extraction protocols and the automatic addition of an internal standard prior to the extraction minimises matrix interference. Robustness and sensitivity are enhanced through online sample clean-up and enrichment via Thermo Scientific TurboFlow technology.

The system is controlled by Thermo Scientific Aria MX software, which streamlines dried spot analysis by fully integrating all aspects of the workflow, such as sample card handling; LC pump operation and valve switching; online sample clean-up; and liquid chromatography-tandem mass spectrometry methods. Furthermore, the Intelligent Vision Camera provides data integrity and enables retrospective monitoring by capturing sample traceability, chain of custody and spot recognition.