Waters Synapt G2-Si Mass Spectrometer

The Waters Synapt G2-Si Mass Spectrometer integrates a third dimension of resolution and separation power into a suite of untargeted and targeted LC/MS/MS workflows. The powerful tool gives researchers a means with which to gain a deeper understanding of molecular biology and disease mechanisms; to develop the next generation of healthcare treatments or chemical materials; and to screen food products or environmental samples for contaminants.

The product combines the power of travelling wave (T-Wave) ion mobility separations with new data acquisition and informatics technologies and collision cross-section (CCS) measurements to bring to tough analytical applications. It is said to be the first MS system to elevate CCS alongside retention time and mass-to-charge ratio (m/z) as a robust identification parameter in library-based screening. Integrating separation by CCS into targeted and untargeted experiments through high-definition, data-directed analysis (HD-DDA) and high-definition multiple reaction monitoring (HD-MRM) modes brings benefits to challenging qualitative and quantitative applications.

The system can separate individual isomers, conformers and isobaric compounds; help determine sites of biotransformation; study structure at physiological concentrations; comprehensively profile complex mixtures; and minimise false positives and negatives in screening experiments.