MP Biomedicals SARS-CoV-2 recombinant antigens and antibodies

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To join the fight against the 2019 novel coronavirus (COVID-19), MP Biomedicals now offers three monoclonal antibodies from mouse and five recombinant antigens for SARS-CoV-2, expressed in E. coli and HEK293.

Recent scientific studies have discovered heightened affinity of the SARS-CoV-2 spike (S-protein) to the human ACE2 cellular receptor. The spike protein (S-protein) contains two subunits, S1 and S2. S1 defines the range of hosts and specificity of the virus, and thus recognises and binds with the cell surface receptor. The S2 subunit contains basic elements needed for membrane fusion. MP Biomedicals now offers three monoclonal antibodies from mouse with high affinity to the SARS-CoV-2 spike (S1 and S2) proteins for use in various applications, including western blot, immunoprecipitation, ELISA tests, rapid tests and flow cytometry.

In addition to antibodies, a selection of recombinant protein antigens for SARS-COV-2 expressed in E. coli and HEK293 cells are also available. These include not only the spike protein, but also the nucleocapsid protein and host receptor ACE2. The company’s in-house validation (slot blot analysis) has observed high sensitivity and affinity for SARS-CoV-2 spike antibodies (4.06-67.5 ng) when tested against SARS-CoV-2 spike protein (S1+S2) (see image).

The company’s anti-coronavirus antibodies include: (i) anti-coronavirus (SARS-CoV-2) spike S1, mouse, mAb; (ii) anti-coronavirus (SARS-CoV-2) spike S2, mouse, mAb; and (iii) anti-coronavirus (SARS-CoV-2) (B) spike S2, mouse, mAb.

The company’s SARS-CoV-2 recombinant antigens include: (i) SARS-CoV-2 Nucleocapsid Protein, His tag (E. coli); (ii) SARS-CoV-2 Nucleocapsid Protein, His tag (HEK293 cells); (iii) SARS-CoV-2 Spike Protein (S1+S2), His tag (HEK293 cells); (iv) ACE2, His tag (E. coli); and (v) ACE2, His tag (HEK293 cells).

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