Cosmo Bio Histone H3 and modified Histone H3 antibodies

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Histones are the main protein components of chromatin. To facilitate nuclear packaging and control of gene expression, DNA in chromatin is wound around nucleosome particles composed primarily of the Histones H2A, H2B, H3 and H4. Histone N-terminal regions (histone tails) protrude from the nucleosome core and are subject to a variety of reversible, regulated modifications (including acetylation, phosphorylation and methylation) influencing transcription and chromatin structure.

How such modifications are regulated, and how these modifications affect gene expression, continues to be an area of intense interest and research. In such studies, chromatin immunoprecipitation (ChIP) is a widely used experimental procedure. Due to the inherent variability and limited supply of polyclonal antibodies, well-characterised monoclonal antibodies are preferred reagents for ChIP. The versatile set of anti-histone monoclonal antibodies offered by Cosmo Bio is therefore a valuable addition to any lab’s epigenetic toolbox.

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