GenomONE-CAb Antibody Delivery Reagent

Wednesday, 15 February, 2012 | Supplied by: United Bioresearch Products Pty Ltd

If target molecules in living cells can be exposed to antibodies, it would be possible to pursue new dimensions of research related to cell function analysis and exploration of target molecules for disease diagnosis and treatment.

GenomONE-CAb Antibody Delivery Reagent is a tool for antibody introduction into cells in order to analyse intracellular function. With this kit, the antibody can be incorporated into the HVJ Envelope (HVJ-E), a transfection tool making use of the membrane fusing ability of inactivated Sendai virus (HVJ: Hemagglutinating Virus of Japan). It is then possible to achieve efficient introduction of the IgG antibody into the cytoplasm.

The different approach of this kit overcomes the difficulties involved in experiments using conventional lipid-based reagents by which antibodies are introduced into cells by means of endocytosis. Unlike post-transcriptional gene silencing (eg, RNAi method), this method is expected to achieve specific inhibition by recognising protein-protein interactions or post-translational modifications (addition of sugar chains, etc). Furthermore, non-specific reactions (off-target effects of RNAi method, etc) are unlikely to occur.

Unlike gene transfer and expression methods, introduction of antibody in amounts sufficient to exert efficacy can be achieved rapidly and simply, and this method is applicable to a wider range of types of experiments.

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