AdipoGen Life Sciences immunometabolism research compounds

Immunometabolism describes the ability of the immune system to communicate and coordinate systemic metabolic homeostasis. Adipose tissue illustrates best the interdependency of both arms of immunometabolism (whole-body metabolism and microscopic metabolism) and provides examples of changes in both the lean and obese states. Lean adipose tissue is characterised by an enrichment of immune cells whose phenotype and cytokine profiles maintain a state of type 2 immunity necessary for the health of the tissue.

Obesity is characterised by an accumulation of inflammatory immune cells and loss of protective lymphocytes due to change in the composition of fatty acids, glucose and oxygen availability that may provide different metabolic substrates to immune cells and adipocytes. AdipoGen Life Sciences offers a broad range of immunometabolism small molecule modulators of glycolysis, TCA cycle, fatty acid oxidation, fatty acid synthesis and amino acid pathways, as well as OXPHOS, GAPDH, PFKII and Nampt inhibitors.