AdipoGen Life Sciences tubulin products for neurodegeneration research

Thursday, 22 October, 2020 | Supplied by: Sapphire Bioscience


Microtubules (MTs) are the largest cytoskeletal components involved in intracellular transport (cell signalling), cell migration/trafficking, cell division and proliferation. Despite their functional diversity, all microtubules are assembled from heterodimers of α‑tubulin and β‑tubulin. Regulation of MT polymerisation is controlled by microtubule associated proteins, post-translational modifications of tubulin α and β, microtubules and signalling molecules.

Posttranslational modifications (PTMs) are dynamic and often reversible processes, where protein functional properties are altered by addition of a chemical group or another protein to its amino acid residues. Tubulins and microtubules (MTs) are major substrates for PTMs.

Deregulation of the neuronal cytoskeleton/MT function constitutes a key insult during the pathogenesis of nervous system diseases, leading to neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer’s disease, hereditary spastic paraplegia, Parkinson’s disease and others.

AdipoGen Life Sciences offers a broad range of microtubule research solutions. This includes tubulin-specific antibodies, unique and validated post-translational modification-specific antibodies and Rab1-GTP and Rab6-GTP specific antibodies.

Online: www.sapphirebioscience.com
Phone: 02 9698 2022
Related Products

Cayman Chemical Bio-Active Lipid I Screening Library (96-Well)

Cayman Chemical's Bio-Active Lipid I Screening Library consists of 13 plates and contains...

Echelon Biosciences ionisable lipids

Echelon Biosciences' ionisable lipids are the key components of lipid nanoparticles (LNPs)...

BioStatus CyTRAK Orange fluorescent dye

BioStatus's CyTRAK Orange is a novel fluorescent dye that preferentially stains the nucleus...


  • All content Copyright © 2025 Westwick-Farrow Pty Ltd