Corning’s Synthemax and Osteo Assay surfaces

Corning Synthemax surface, a novel synthetic surface that supports the growth and differentiation of stem cells, is now available as a 6-well plate or 75 cm flask.

Corning has worked with Geron to develop synthetic surface matrices to support the scalable manufacturing of stem cells and differentiated cell types (eg, cardiomyocytes). Synthetic growth surfaces can replace biological surface coatings used with pluripotent stem cells and can offer increased reproducibility, cost savings and regulatory advantages.

The Synthemax surface supports scalable expansion of stem cells for more than 20 serial passages in defined xeno-free medium with: stable doubling time, phenotypic marker expression, retention of normal karyotype and maintenance of pluripotency.

The Osteo Assay surface is a three-dimensional structure that mimics in vivo bone for in vitro bone cell assays. This inorganic bone biomaterial surface in a 96- or 24-well plate is capable of supporting the functional properties of osteogenic cells.

The Osteo Assay surface is designed for: direct assessment of osteoclast and osteoblast functional in vitro activity; osteoclast and osteoblast precursor differentiation; co-culture of osteoclast and/or osteoblasts with other cell lines; solution-based quantitative assays; and studies related to bone remodelling and pit formation.