Merck Sucrose EMPROVE EXPERT Ph Eur, ChP, JP, NF
Merck has developed a filtration-based manufacturing process resulting in a highly purified sucrose grade with reduced levels of nanoparticle impurities (NPI). The product — Sucrose EMPROVE EXPERT Ph Eur, ChP, JP, NF — is suitable for the high-risk applications of manufacturing and formulating biomolecules.
As a widely used protein stabiliser for biomolecule formulation, the quality of sucrose is crucial. Collaborating with Coriolis Pharma, Merck designed the purification process and associated nanoparticle analytics of sucrose.
The result is a highly pure sucrose that is said to offer the following benefits over non-purified sucrose: a low level of NPIs on the limit of detection of current technologies, reducing the risk for protein instability; less interference with analytical methods; high batch-to-batch consistency; and reduced risk of API damage.
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