As a tool, conventional mass spectrometry is a good method for differentiating between proteins with different masses. However, as different folded forms of a particular protein have identical masses, it is virtually impossible to differentiate them by conventional means. That's where the Waters Synapt HDMS system and its embedded ion mobility technology can help.
Dietary fibre including cellulose, hemicelluloses, lignin, pectin, rubbers and waxes can be determined by digestion with thermostable enzymes in foods and animal feeds. AOAC International (Official Methods of Analysis) has proposed enzymatic method 985.29.
Physicists at NIST-Boulder have carried out a powerful new spectroscopic study of a gas sample using optical frequency combs.
Thermo Fisher Scientific has been awarded a US Patent on Spectrometric Data Cleansing. This patent describes a method for filtering artefacts from Raman spectra and is of particular use in removing the distorted data points generated by cosmic ray interference. Elimination of spectral artefacts facilitates automated analysis by such methods as reference library searches and correlation with standard spectra.
Researchers have solved the structure of a DNA-protein complex that is crucial in the spread of antibiotic resistance among bacteria, providing insights into how cells successfully divide into two new cells with intact DNA.
US scientists have modelled an enzyme critical to the process of DNA transcription and replication which could be a prime target for antibacterial and anticancer drugs.